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. 2019 Apr 9;13(5):4947–4959. doi: 10.1021/acsnano.8b07662

Figure 2.

Figure 2

Chemical characterization of polymer–PCS5 conjugates. (A) CS–PCS5 final conjugate, (i) schematically represented, (ii) 1H NMR of CS, PCS5, and CS–PCS5 conjugate. Blue arrows indicate the signals from the aromatic rings and isopropyl groups of PCS5 and orange arrows the glucosamine units of CS, both observed in the NMR of the conjugate. (B) HA–PCS5 conjugate (i) schematically represented, (ii) 1H NMR of HA, PCS5, and HA–PCS5 conjugate. These results corroborated the presence of both the PCS5 characteristic signals (blue arrows) and the acetyl groups of HA (orange arrows) in the conjugate. Key: CS, chitosan; PCS5, protease cleavage site 5; HA, hyaluronic acid.