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. 2019 Jun 26;10:817. doi: 10.3389/fphys.2019.00817

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Copyright © 2019 Lasser, Pratt, Monahan, Kim and Lowery.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chromosome 4 and WHS-associated genes. All genes are represented in their order from left to right, telomeric to centromeric orientation, located on the distal arm of chromosome 4p16.3. Brackets delineate WHS critical region 1 (WHSCR1), comprised of LETM1 and WHSC1, and WHS critical region 2 (WHSCR2), comprised of WHSC1 and WHSC2. Genes that are also mutated in WHS patients consist of PIGG, CPLX1, FGFRL1, CTBP1, SLBP, TACC3, and FGFR3, which flank the WHS critical regions.