Table 1.

Evidence Profile Table

Study Characteristic	Data
No. of randomized clinical trials	16
Study years	Conducted, 2006-2016; published, 2008-2018
Date of literature search	1940-July 23, 2018
No. of patients	5,158 randomized; 5,000 analyzed
Race/ethnicity	Unavailable
Age	Adults
Setting	ICUs
Countries	Australia, Brazil, China, France, Germany, Netherlands, Serbia, Switzerland, USA
Comparison	Procalcitonin-guided antibiotic discontinuation vs control group
Primary outcome	Mortality (28-d mortality or hospital mortality)
Secondary outcomes	Antibiotic duration and length of stay