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. Author manuscript; available in PMC: 2019 Dec 5.
Published in final edited form as: J Am Chem Soc. 2018 Nov 19;140(48):16450–16454. doi: 10.1021/jacs.8b11150

Table 3.

Hydrophosphinylation of 1a with Various Phosphine Oxidesa

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a

Reaction conditions: 1a (0.12 mmol), 2 (0.10 mmol), Pd2(dba)3 (2.5 mol%), ligand (5.0 mol%), (Ph)2P(O)OH (20 mol%), toluene (0.40 mL), 6 h. Isolated yield of 3. Regioselectivity ratio (rr) is the ratio of 3 to 4, which is determined by 31P NMR analysis of reaction mixture. Enantioselectivity determined by chiral SFC. See SI for full structure of abbreviations used.

b

Reaction time is 24 h.