TABLE X.
Gene Signatures1 of 1,25D Exposure in Mammary-Derived Cell Lines (hTERT-HME, MCF7, SKBR3) and in Breast Tumor Explants
| Genes common to all 3 cell lines |
Genes common to MCF7 and SKBR3 |
Genes common to hTERT-HME and SKBR3 |
Genes common to all 4 datasets |
|---|---|---|---|
| CLMN (↑) | CLMN (↑) | CLMN (↑) | CLMN (↑) |
| CYP24A1 (↑) | CYP24A1 (↑) | CYP24A1 (↑) | CYP24A1 (↑) |
| EFTUD1 (↑) | EFTUD1 (↑) | EFTUD1 (↑) | EFTUD1 (↑) |
| IL1RL1 | IL1RL1 | IL1RL1 (↑) | IL1RL1 |
| SERPINB1 (↑) | SERPINB1 (↑) | SERPINB1 (↑) | SERPINB1 (↑) |
| BHLHE40 | BHLHE40 | BHLHE40 | |
| CD97 (↑) | CD97 (↑) | CD97 (↑) | |
| ETS2 | ETS2 | ETS2 | |
| G6PD | G6PD | G6PD | |
| IGFBP3 | IGFBP3 | IGFBP3 | |
| NDRG1 (↓) | NDRG1 (↓) | NDRG1 (↓) | |
| RGNEF (↑) | RGNEF (↑) | RGNEF (↑) | |
| SDC3 (↓) | SDC3 (↓) | SDC3 (↓) | |
| SLC26A2 | SLC26A2 | SLC26A2 | |
| TIMP3 (↑) | TIMP3 (↑) | TIMP3 (↑) | |
| TRPV6 (↑) | TRPY6 (↑) | TRPV6 (↑) | |
| VLDLR | VLDLR | VLDLR | |
| ACOX3 | ARSJ (↓) | ||
| AREG (↑) | BDKRB1 (↑) | ||
| ARHGEF6 | DNAJB1 | ||
| CDK6 (↓) | DUSP1 | ||
| CEACAM6 (↑) | EFNA1 (↑) | ||
| CEBPB (↑) | EFNB2 (↑) | ||
| CYP1A1 (↑) | GRK5 | ||
| DHRS3 | HR | ||
| FAM46C | KLF14 | ||
| ITPR1 (↑) | KRT16 (↑) | ||
| MB | MALL | ||
| MERTK (↑) | RASD2 (↑) | ||
| NFKBIA | RASSF5 | ||
| PADI3 (↑) | RIPK4 | ||
| PGM2L1 (↑) | SEMA3B (↑) | ||
| PHLDB2 (↑) | SERPINB6 | ||
| PISD (↑) | SRGAP3 (↓) | ||
| SMOX (↑) | TMEM40 | ||
| STEAP4 (↑) | TTC7A (↑) | ||
| SULT2B1 | |||
| TGIF1 | |||
| TMPRSS2 (↑) | |||
| TSKU (↑) | |||
| ZNF703 (↑) | |||
1
Gene signatures were compiled as described in Methods by integrating the hTERT-HME and MCF7 datasets reported here with those of Goerman et al. (22) and Milani et al. (26).