Figure 1.

CONSORT diagram. ^aOne patient in the placebo group was randomized and dosed, but was excluded from the modified intent‐to‐treat (mITT) analysis set because screening and baseline pulmonary capillary wedge pressure (<20 mmHg) was below the minimum required for inclusion, and thus was not eligible for study entry as acknowledged by the investigator and confirmed by the study medical monitor and dose‐escalation review committee. AE, adverse event; HF, heart failure; PK, pharmacokinetic.