Table 3.

Changes in quality of life in the pooled heart failure population

	Baseline observed	6‐month active therapy		12‐month active therapy
		Observed	Paired changefrom baseline	Observed	Paired changefrom baseline
Moderate or marked improvement in PGA	N/A	N/A	58 (47/81)	N/A	55 (41/75)
Epworth Sleepiness Scale*	8.9 ± 5.1 (93) 8.0 [5.0–13.0]	6.2 ± 4.1 (81) 6.0 [3.0–9.0]	–2.8 ± 4.5 (81) –2.0 [–6.0 to 0.0] P < 0.001	6.1 ± 3.7 (75) 5.0 [3.0–9.0]	–3.1 ± 4.7 (75) –2.0 [–5.0 to 0.0] P < 0.001
Minnesota Living with Heart Failure score*	39.2 ± 22.8 (91) 40.0 [21.0–55.0]	35.3 ± 24.3 (81) 32.0 [16.0–52.0]	–2.6 ± 19.2 (79) –1.0 [–12.0 to 7.0] P = 0.227	31.0 ± 22.8 (75) 27.0 [13.0–46.0]	–6.8 ± 20.0 (73) –4.0 [–18.0 to 8.0] P = 0.005

Values are mean ± standard deviation (n), or median [interquartile range] for continuous data, or % (n/N) for categorical data.

N/A, not applicable; PGA, patient global assessment.

^*Nominal two‐sided P‐value from paired t‐test for change from baseline.