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. 2019 Jul 2;16:134. doi: 10.1186/s12974-019-1525-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Relapsing disease course in the 66 treated patients from the total cohort. AZT, azathioprine; MMF, mycophenolate mophetil; RTX, rituximab; MS-DMD, multiple sclerosis disease-modifying drugs; CYC, cyclophosphamide; MTX, methotrexate; MiTX, mitoxantrone; CS, corticoids; i.v.Ig, intravenous immunoglobulins. *Patients Id.4, Id.20, Id.60, Id.62 and Id.63 followed therapies in combination (detailed in (Additional file 1: Table S5). **Treatment information in patients Id.2, Id.22, Id.47 and Id.66 is not depicted when started 20 years from the onset of symptoms