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. 2019 Jul 3;18:114. doi: 10.1186/s12943-019-1043-x

Table 1.

Variety of positive rate of CTCs in HCC

Region HCC patients Background liver status Methodology Positive rate Ref.
China 139

HBVa: 85%

LCb: 74%

 CellSearch™ (Pre/post)

43.9 %

54.0%

 Yu et al [34], 2018
China 112 HBV: 75% CanPatrol 90.18% Qi et al [35], 2018
Germany 57

CVHc:21%

LC: 24%

Alcohol: 7%

NASHd: 10%

 CellSearch™ 15.8% von Felden et al [36], 2017
United Kingdom 69

Alcohol: 32%

NAFLDe:35%

PBCf/AIHg:13%

LC: 71%

 ImageStream 65.2% Ogle et al [37], 2016
China 36 Not applicable CTC-Chip 100% Zhang et al [38], 2016
China 42

HBV: 81%,

HCVh: 2%,

nonB, nonC: 17%

 CTC-Chip 59.5% Wang et al [39], 2016
United States 20

HBV: 25%, HCV: 45%

HBV and HCV: 10%

Alcohol: 5%

NAFLD: 10%

 CellSearch™ 40.0% Kelley et al [40], 2015
South Korea 81

HBV: 80%,

HCV: 11%,

Alcohol: 4%

LC: 59%

 RT-PCRi (K19, CD44) 22.2% Choi et al [41], 2015
Egypt 70 HCV: 100% Flow Cytometry (CK19, CD133, CD90)

73%

69.5%

49.8%

 Bahnassy et al [42], 2014
China 299

HBV: 90%

LC: 90%

 CellSearch™ 42.6% Guo et al [43], 2014
United Kingdom 52

Alcohol: 38%,

HBV: 8%

Diabetes: 12%

CellSearch™

ISETj

28%

100%

 Morris et al [44], 2014
China 42 LC: 55% CellSearch™ 52.3% Fang et al [45], 2014
China 27 Not applicable CellSearch™ 88.9% Li et al [46], 2013
Germany 59

Alcohol: 38%,

HBV: 17%,

HCV: 13%

LC: 89%

 CellSearch™ 30.5% Schulze et al [47], 2013
China 123

HBV: 75%

LC: 76%

 CellSearch™ 66.6% Sun et al [48], 2013
China 60

HBV: 93%

LC: 93%

 Flow cytometry 50.0% Liu et al [49], 2013
China 85

HBV: 84%,

HCV: 7%,

HBV and HCV: 5%,

nonB, nonC: 4%

 CellSearch™ 81.0% Xu et al [50], 2011
China 82 HBV: 80% CellSearch™ 68.3% Fan et al [51], 2011
France 44 LC: 89% ISET 52.2% Vona et al [52], 2004
China 30

HBV:100%,

LC: 100%

 RT-PCR (MAGE1/3) 43.3% Mou et al [53], 2002

aHepatitis B Virus

bLiver cirrhosis

cChronic viral hepatitis

dNon-alcoholic steatohepatitis

eNon-alcoholic fatty liver disease

fPrimary biliary cirrhosis

gAutoimmune hepatitis

hHepatitis C Virus

iReverse transcriptase polymerase chain reaction

jIsolation by size of epithelial tumor cells