Fig. 4.

Performance assessment of ACT and alternative miRNA-related metrics The gene lists derived from different ranked metrics (binding energy, pairing score, and ACT) were subjected to pathway enrichment analysis. Each bar represents a circRNA or random transcript according to the label on the x axis. The top row shows the number of pathways while the bottom row shows the p-value estimated through a permutation test drawing from the full target gene list of circRNA-associated miRNAs. sponge: circRNAs with known sponge activity to multiple miRNAs. -sponge: nuclear circRNA without known miRNA sponge activity. circRNAs: a group of circRNA with unknown molecular function. Transcripts: random transcript as background dataset