Table 2.
The experiments and noise exposure, drug, and animal model variables listed for each systemic rescue experiment discussed in Section “Local delivery of Oto-Protective Compounds to the Cochlea.”
| Experiment | Compound | Animal | Compound delivery | Noise duration and dB SPL | Time of first injection | Subsequent Injections | Efficacy |
|---|---|---|---|---|---|---|---|
| Zhu et al., 2018 | Dexamethasone or TAAC | Guinea pig | Hydrogel | 3 h – 120 dB SPL | Immediately post-noise | None | None (TAAC), Partial (DEX) |
| Mamelle et al., 2018 | Dexamethasone | Guinea pig | Hydrogel | 1 h – 100 dB SPL | 48 h post-noise | None | None |
| Harrop-Jones et al., 2016 | OTO-104 or Dexamethasone | Guinea pig | Hydrogel (OTO-104), solution (DEX) | 2 h – 105 or 110 dB SPL | 1 day prior, 2, 3, or 4 days post-noise | None | Partial (OTO-104), None (DEX) |
| Chi et al., 2011 | Dexamethasone | Albino guinea pig | Gelfoam | 80 impulses – 167 dB pSPL | 1 day post-noise | None | Partial |
| Sendowski et al., 2006 | MP | Guinea pig | Intracochlear osmotic pump | 3 impulses – 170 dB pSPL | Immediately post-noise | Continuously for 7 days | Partial |
| Zhou et al., 2009 | MP | Guinea pig | Solution | 60 impulses – 165 dB pSPL | 1 h | 4 injections, one every 48 h | Partial |
| Han et al., 2015 | Dexamethasone | C57BL.6J mice | Solution | 1 h – 110 dB SPL | 1 day post-noise | 4 days after noise | Nearly complete |
| Alagic et al., 2011 | D-methionine | Guinea pig | Solution | 45 min – 100 dB | 90 min prior | None | Partial |
| Zou et al., 2003 | NAC | Guinea pig | Gelfoam | 15 min vibration – 108 dB | 24, 48, or 72 h or 7 days prior | None | None |
| Bielefeld et al., 2013 | 4-[2-amino-ethyl]benzenesulfonyl fluoride | Chinchilla | Solution | 6 h – 106 dB SPL or 75 impulses – 155 dB pSPL | Immediately prior | None | Partial (impulse), none (continuous noise) |
| Wang et al., 2007 | D-JNK-1 | Guinea pig | Osmotic pump onto RWM or hydrogel | 15 min – 130 dB SPL | 30 min before, 1, 4, 6, 12 or 24 h post | Continuously for 7 days (osmotic pump), None (hydrogel) | Nearly complete if within 12 h |
| Wang et al., 2003 | D-JNK-1 | Guinea pig | Intracochlear osmotic pump | 30 min – 120 dB SPL | 2 days prior | Continuously for 7 days | Nearly complete |
| Coleman et al., 2007b | AM-111 | Chinchilla | Hyrdogel or osmotic pump | 150 impulses – 155 dB pSPL | 1 or 4 h | None | Partial |
| Wang J. et al., 2002 | Riluzole | Guinea pig | Intracochlear osmotic pump | 30 min – 120 dB SPL | 2 days prior | Continuously for 7 days | Partial |
| Chen et al., 2003b | Caroverine | Guinea pig | Gelfoam | 1 h – 110 dB SPL | 1 or 24 h post | None | Partial if 1 h, None if 24 h |
| Chen et al., 2004 | Caroverine | Guinea pig | Gelfoam | 1 h – 110 dB SPL | 10 min prior | None | Partial |