Table 1. Screening of pregnant women and follow-up of siblings and newborns for Chagas disease, Catalonia, 2010–2015 (n = 40,084).

	Total		2010		2011		2012		2013		2014		2015		Difference 2010–2015	p value 2010 vs 2015
	n	%	n	%	n	%	n	%	n	%	n	%	n	%	%
Pregnancies follow-up
To be testeda	40,084		7,656		7,145		7,099		6,348		6,005		5,831		−23.8	NA
Tested	33,469	83.5	5,238	68.4	6,107	85.5	6,324	89.1	5,524	87.0	5,108	85.1	5,168	88.6	29.5	< 0.001
Positives	937	2.8	128	2.4	179	2.9	168	2.7	163	3.0	148	2.9	151	2.9	19.6	0.147
Lost before parturitionb	38	4.1	8	6.3	8	4.5	11	6.5	3	1.8	3	2.0	5	3.3	−47.0	0.381
Miscarriages/abortionsb	87	9.3	7	5.5	16	8.9	17	10.1	18	11.0	14	9.5	15	9.9	81.6	0.248
Gave birthb	812	86.7	113	88.3	155	86.6	140	83.3	142	87.1	131	88.5	131	86.8	−1.7	0.840
Other children follow-up
Siblings to be tested	519		130		84		92		73		73		67		−48.5	NA
Missing information/not tested	341	65.7	121	93.1	42	50	44	47.8	49	67.1	52	71.2	33	49.3	−47.1	< 0.001
Tested	178	34.3	9	6.9	42	50.0	48	52.2	24	32.9	21	28.8	34	50.7	633.0
Positives	14	7.9	2	22.2	3	7.1	2	4.2	2	8.3	2	9.5	3	8.8	−60.3	0.596
Negatives	164	92.1	7	77.8	39	92.9	46	95.8	22	91.7	19	90.5	31	91.2	17.2
Newborns follow-up
1. Parasitological control at birth
Not tested	84	10.3	19	16.8	30	19.4	13	9.3	7	4.9	6	4.6	9	6.9	−59.1	0.026
Tested	728	89.7	94	83.2	125	80.6	127	90.7	135	95.1	125	95.4	122	93.1	12.0
Tested by PCR	634	87.1	83	88.3	100	80.0	110	86.6	122	90.4	111	88.8	108	88.5	0.3	0.871
Tested by MH	419	57.6	73	77.7	59	47.2	69	54.3	75	55.6	73	58.4	70	57.4	−26.1	0.003
Positives	12	1.6	2	2.1	2	1.6	1	0.8	4	3.0	3	2.4	0	0	−100.0	0.367
Negatives	716	98.4	92	97.9	123	98.4	126	99.2	131	97.0	122	97.6	122	100	2.2
2. Serological control at age 9–12 months
To be tested	800		111		153		139		138		128		131		18.0	NA
Not tested	140	17.5	21	18.9	33	21.6	31	22.3	26	18.8	12	9.4	17	13.0	−31.4	0.276
Moved away from Catalonia	56	7.0	1	0.9	13	8.5	13	9.4	17	12.3	9	7.0	3	2.3	154.2	0.735
Failure to attend the medical visit	53	6.6	15	13.5	9	5.9	9	6.5	8	5.8	2	1.6	10	7.6	−43.5	0.199
Failure of surveillance circuitc	31	3.9	5	4.5	11	7.2	9	6.5	1	0.7	1	0.8	4	3.1	−32.2	0.800
Tested	660	82.5	90	81.1	120	78.4	108	77.7	112	81.2	116	90.6	114	87.0	7.3	0.276
Mean time to test (months)	10 ± 4		10 ± 3.5		10 ± 6		10±4		10 ± 4		10 ± 3		9 ± 4
Positives	16	2.4	4	4.4	2	1.7	1	0.9	4	3.6	2	1.7	3	2.6	−40.8	0.750
Negatives	644	97.6	86	95.4	118	98.3	107	99.1	108	96.4	114	98.3	111	97.4	1.9
3. Summary of testing
Correctly tested	672	82.8	92	81.4	122	78.7	109	77.9	116	81.7	119	90.8	114	87	6.9	0.304
Positives	28	4.2	6	6.5	4	3.3	2	1.8	8	6.9	5	4.2	3	2.6	−59.6	0.318
Negatives	644	95.8	86	93.5	118	96.7	107	98.2	108	93.1	114	95.8	111	97.4	4.2
Index
Pregnant women screening coverage rate (%)	83.5		68.4		85.5		89.1		87.0		85.1		88.6		29.5	< 0.001
Prevalence rate of Chagas disease (%)	2.80		2.44		2.93		2.66		2.95		2.90		2.92		19.6	0.147
Congenital transmission rate (%)	4.17		6.52		3.28		1.83		6.90		4.20		2.63		−59.6	0.318

NA: not Applicable.

^a Number of births from the Newborns Registry plus an estimation (13%) of interrupted pregnancies and women who moved away before childbirth from the Voluntary Registry of Chagas disease congenital cases in Catalonia.

^b Among the women who tested positive.

^c Missing patient referral or paediatrician’s lack of awareness about Chagas disease.