Skip to main content
. Author manuscript; available in PMC: 2019 Jul 3.
Published in final edited form as: Science. 2018 Jun 1;360(6392):1010–1014. doi: 10.1126/science.aat4133

Fig. 3. Synthesis of trifluoromethyl(hetero)arenes.

Fig. 3

Substrate scope for the metallaphotoredox-catalyzed trifluoromethylation of (hetero)aryl bromides. All yields are isolated unless noted otherwise. See the supplementary materials for experimental details and more examples. *With photocatalyst 14. †With photocatalyst 1. ‡Yield determined by 19F or proton nuclear magnetic resonance (1H NMR) of crude reaction mixture with respect to an internal standard. §With 20 mol % 1,10-phenanthroline. ||Copper(I)-thiophene-2-carboxylate as catalyst. With 20 mol % 4,7-dimethoxy-1,10-phenanthroline. Ac, acetyl; Pin, pinacolato; Boc, tert-butoxycarbonyl; Et, ethyl; Ts, 4-toluenesulfonate.