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Sparing of PCP2-negative cone BCs. Sections were immunostained with antibodies for PCP2 (magenta) and CaBP5 (green), which is expressed in rod BCs and cone type 5-ON and type 3-OFF BCs. Vps34fl/fl controls and Vps34fl/fl;Pcp2-Cre retinas at (A) 3 months and (B) 10 months. At 10 months, very few PCP2-positive cells remain in Vps34fl/fl;Pcp2-Cre retinas, whereas other BCs labeled with CaBP5 were spared.
