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. 2019 Jun 26;10:1422. doi: 10.3389/fimmu.2019.01422

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Copyright © 2019 Malamud, Carasi, Assandri, Freire, Lepenies and Serradell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The adjuvant capacity of SLP-8348 is a glycan-mediated process. BALB/c mice were subcutaneously injected with one dose (10 μg/mouse) of SLP-8348 + OVA, oxidized SLP-8348 (SLPOx-8348) + OVA, PBS + OVA (OVA), or PBS (PBS). Cells were labeled with CFSE and stimulated in vitro with OVA (10 μg/ml) for 5 days. Proliferation index of CD4⁺ T cells in each experimental group was calculated as the ratio between the percentage of CFSE ^low CD4⁺ cells and CFSE^low CD4⁺ cells from OVA-treated mice (A). IFN-γ levels in supernatants (B). A representative figure of three independent experiments is shown (±SD, indicated by error bars). Asterisks indicate statistically significant differences by one-way ANOVA with Tukey's post hoc test (^*p < 0.05).