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. 2019 Jun 26;10:1422. doi: 10.3389/fimmu.2019.01422

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Copyright © 2019 Malamud, Carasi, Assandri, Freire, Lepenies and Serradell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SLP-8348 is recognized and internalized by specific CLRs expressed on BMDCs. CLR-hFc fusion proteins were analyzed for the interaction with SLP-8348. Inhibition assays were performed using EGTA, a Ca²⁺ chelating agent (A). Binding (4°C, squares) and internalization (37°C, circles) of Atto 647N-labeled-SLP-8348 at different concentrations on CD11c⁺ cells from C57BL/6 mice and CLR-deficient mice (B) A representative figure of three independent experiments is shown (±SD, indicated by error bars). Asterisks indicate statistically significant differences by one-way ANOVA with Tukey's post hoc test (^*p < 0.05).