Figure 2.

The role of STAT5B in the GHR intracellular signaling pathways. Following recruitment to activated receptors, the latent cytosolic STAT5B protein is phosphorylated on a single tyrosine at position 699 by kinases, including JAK2, which serves to facilitate subsequent homodimerization. The dimeric STAT5B is then mobilized into the nucleus where binding to DNA response elements regulate transcriptional activities. AKT, v-akt murine thymoma viral oncogene homolog, also known as protein kinase B; PI3K, phosphatidylinositol 3-kinase; P, phosphorylated residue; Y, tyrosine.