Figure 5.

Reduced natural cytotoxicity by FK506. (A) Human NK cells cultured as in Fig. 2 were subject to ⁵¹Cr release assay against K562, CEM, and U937 targets. For redirected ADCC (rADCC), effector cells were preincubated with anti‐human 2B4 prior to exposure to FcR⁺P815 targets. The data are representatives from 5 independent experiments, and error bars represent sd out of triplicates. (B) NK cells upon stimulation by K562 target cells were analyzed for CD107a degranulation events. The right panel shows the relative percentages of CD56⁺ CD107a⁺ populations compared with those of vehicle control (n=8). Error bar represents sd (***P<0.001). One sample t test was performed by SPSS.