Skip to main content
. 2016 Oct 12;101(1):77–86. doi: 10.1189/jlb.2MR0416-201R

Figure 3.

Figure 3

The mTORC1 pathway: effect on TLR signaling cascades and modulation by bacteria. mTORC1 is activated primarily downstream of growth factor receptors (receptor tyrosine kinase) via the PI3K‐AKT‐TSC pathway or by amino acids in the cytoplasm. mTORC1 activates 4EBP1 and S6K, which promote protein translation. mTORC1 is also the main cytosolic inhibitor of autophagy. mTORC1 regulates TLR signaling via activation of MAPK and STAT3 or inhibition of NF‐κB. The mTORC1 pathway is modulated by pathogenic bacteria through the inhibition of AKT (in response to L. pneumophila) or amino acid starvation (in response to S. typhimurium). TRIF = TIR (Toll/IL‐1R) domain‐containing adapter inducing IFN‐β.