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. 2016 May 6;100(5):919–926. doi: 10.1189/jlb.2MR0216-063R

Figure 1.

Figure 1

TRAF family molecules. A schematic depiction of the basic structural features of the TRAF molecules. All except TRAF1 have an N‐terminal Zn‐binding RING domain, followed by a variable number of Zn finger motifs. The coiled‐coil/TRAF‐N domain allows TRAFs to form homo‐ or heteromultimers. All except TRAF7 have a C‐terminal TRAF‐C domain used to mediate many of their protein–receptor and protein–protein interactions. TRAF7 has a unique C‐terminal structure containing multiple WD40 domains [10]. TRAF4 and recently, TRAF3 are reported to have canonical NLS sequences [11, 12].