Table 1.

Regulatory functions of TRAF3 in B and T lymphocytes

B cells	T cells
Inhibition of NF‐κB2 activation	Inhibition of NF‐κB2 activation
Inhibition of homeostatic survival	Enhancement of TCR signaling
Inhibition of CD40 and BAFFR signaling	Inhibition of IL‐2R signaling
Promotion of LMP1 signaling	Promotion of ICOS expression in Tregs
Inhibition of TLR signaling
Inhibition of IL‐6R signaling and plasma cell differentiation
Nuclear interaction with CREB complex; inhibition of CREB‐mediated transcription