Figure 5.
MDSCs derived from PBMC or bone marrow are both suppressive. An allogeneic 3‐way MLR was performed on MDSCs derived from PBMCs or bone marrow. APCs and T cells were cultured with no MDSCs and various ratios of MDSCs to T cells (1:8, 1:4, and 1:2). The inhibition of [3H]thymidine incorporation was evaluated. Results are represented as percentages of inhibition, where 100% is the condition without MDSCs. Replicate (3–5) wells were performed for each condition. ∗P < 0.05 indicates significant difference when compared with the condition without MDSCs.