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DGL is dispensable for TRP activation by DAG. A, Following reduction of the constitutive TRP activity by ATP in a trpl patch, the lipase inhibitor RHC-80276 (250 μm) was added and in its presence we applied DAG, which activated the channel, and responded to a subsequent ATP addition (n = 4). B, In the ninaE;trpl double mutant, DAG activates a silent TRP patch despite the presence of the lipase inhibitor, and ATP turned it off (n = 3).
