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. 2014 May 7;34(19):6647–6658. doi: 10.1523/JNEUROSCI.5390-13.2014

Figure 1.

Figure 1.

Effects of the combination of extinction training with ChABC injections into the amygdala on the subsequent reinstatement of morphine-induced CPP. A, Timeline of experimental procedure (see Materials and Methods for the experimental conditions of the groups). B, C, The combination of extinction training with microinfusions of chondroitinase ABC (0.01 U/side) and penicillinase (0.01 U/side) into the BLA (B) or CeA (C) but not 2 mm dorsal to the amygdala (D) prevented the subsequent drug-induced reinstatement of morphine-induced CPP. A significant difference was found in the morphine-induced priming test between the ChABC group and other two groups. E, Approximate placements of the intracranial injectors. The data are expressed as the mean ± SEM preference scores in seconds (time spent in the morphine-paired chamber minus time spent in the saline-paired chamber) during the CPP tests. *p < 0.05 vs vehicle group (n = 8–10 per group). Post-C, Postconditioning test; Post-E, postextinction test.