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. 2014 May 7;34(19):6647–6658. doi: 10.1523/JNEUROSCI.5390-13.2014

Figure 5.

Figure 5.

Effects of combination of extinction training with ChABC injection into the amygdala on the subsequent reinstatement of cocaine-induced CPP. A, D, Timeline of experimental procedure. B, C, Combination of extinction training with microinfusions of chondroitinase ABC (0.01 U/side) into the BLA (B) or CeA (C) 1 d after the postconditioning test prevented the subsequent cocaine-priming-induced reinstatement of cocaine-induced CPP. A significant difference was found in cocaine-priming test between the ChABC group and the vehicle group. E, F, Combination of extinction training with microinfusions of chondroitinase ABC (0.01 U/side) into the BLA (E) or CeA (F) 1 d after the postconditioning test had no effect on subsequent-priming-induced reinstatement of food-induced CPP. The data are expressed as the mean ± SEM preference scores in seconds (time spent in the cocaine- or food-paired chamber minus time spent in the saline-paired chamber) during the CPP tests. *p < 0.05 vs vehicle group (n = 7–10 per group). Post-C, Postconditioning test; Post-E, postextinction test.