Figure 7.

Effects of combination of extinction training with ChABC injection into the amygdala on the subsequent reinstatement of cocaine-seeking behavior. A, Timeline of experimental procedure. B–D, All rats acquired similar heroin self-administration behavior (B), and a combination of extinction training with microinfusions of chondroitinase ABC (0.01 U/side) into the BLA (C) or CeA (D) 1 d after cocaine self-administration training facilitated subsequent extinction training and prevented the reinstatement of cocaine-seeking behavior. A significant difference was found in the rate of extinction training and in the cocaine-induced-priming test between the ChABC group and the vehicle group. The data are expressed as the mean ± SEM number of responses on the active and inactive nose poke devices during the extinction sessions and cocaine-priming test. *p < 0.05 vs vehicle group (n = 7–8 per group).