Schematic of the proposed neural pathway that underlies the salience-evoked pupil response. CG, Ciliary ganglion; CNF, mesencephalic cuneiform nucleus; EW, Edinger–Westphal nucleus; IC, inferior colliculus, PON, pretectal olivary nucleus; SCi, intermediate layers of superior colliculus; SCs, superficial layer of superior colliculus; SCG, superior cervical ganglion; Spinal: spinal cord.