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. 2014 Jan 8;34(2):596–607. doi: 10.1523/JNEUROSCI.2346-13.2014

Figure 3.

Figure 3.

O2 signal recordings during the first 3 weeks of acquisition of a cued lever-press task. A, B, AUC extracted from the O2 signals recorded daily during the first 3 weeks of acquisition of the task simultaneously in the NAc (A) and the IFC (B). *p < 0.05 compared with the S2− cue (global cue effect in the ANOVA). C, D, Representative O2 amperometry curves recorded at different time points during acquisition: the first day the animals are presented with the task (Day 1), and after 5, 11, and 17 d of training. Values are presented as an average ± SEM of 30 rewarded trials (S1+, black circle) and 30 nonrewarded trials (S2−, open circle) presented during the 45 min session for both the NAc (C) and IFC (D). Each trial was analyzed for a 30 s period, including a 5 s baseline before cue onset (dashed line at 0 on the x-axis) and 25 s after. The second dashed line at 10 s corresponds to cue offset. On the first day of acquisition, both the NAc and the IFC show increases in the O2 signal for both S1+ and S2− cues. From Day 5 onward, the O2 signal increase in the NAc is observed only for S1+, while the IFC is activated only during the S2− cue presentation. Black bars: p < 0.05 compared with the S2− cue.