Figure 6.

Deconstruction of behavioral responses associated with cue-dependent O₂ signals recorded during acquisition in the IFC. O₂ signals were recorded during the whole course of acquisition, and average curves for representative days are depicted from the following time points: the first day of acquisition (DAY1); after 5, 11, 17, 22, 28, and 35 d of training; and when the animals were fully trained (DAY50). O₂ signal graphs have been presented as session averages according to the subtype of behavioral response exhibited for each cue: correct lever press (L+) following the S1+ cue (S1+/L+, black circles); omission (OM) following the S2− cue (S2−/OM, white circles); incorrect lever press (L−) following the S1+ cue (S1+/L−, black circles); or lever press (LP) following the S2− cue (S2−/LP, white circles). Each trial was analyzed for a 30 s period including a 5 s baseline before cue onset (dashed line at 0 on the x-axis) and 25 s after. The second dashed line at 10 s corresponds to cue offset. On Day 1, IFC activation is observed for all response subtypes regardless of cue presentation. From Day 5 to Day 22, IFC activates mainly following the S2− cue, regardless of response subtype. From Day 28 to 50, no significant difference could be observed between the different types of response. Black bars, p < 0.05 compared with the S2− OM or LP; dashed bars, p < 0.05 compared with S1+/L- response. Note that S1+/L- responses include both incorrect lever presses and omissions following the S1+ cue and are highly underpowered due to the small number of responses. They were therefore analyzed and represented only when a minimum of four animals could be averaged per session.