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. 2015 Oct 14;35(41):14070–14075. doi: 10.1523/JNEUROSCI.2690-15.2015

Figure 1.

Figure 1.

OB adrenoceptor blockade slows similar odor discrimination learning and pattern separation in the aPC. A, Schematic of experimental procedures. B1–B4, Impaired odor discrimination by adrenoceptor blockade is accompanied by reduced reliability of pyramidal cell activity. B1, Correct responses in the drug and saline groups after six blocks of training. B2, Example images of Arc+ cells in aPC. Blue indicates DAPI staining of nuclei; red indicates Arc signals; white and yellow arrows indicate double- and single-stained Arc+ cells, respectively. Scale bar, 20 μm. B3, OLR of the two ensembles to the same reward odor (S+) in the drug and saline groups. B4, Distribution of Arc+ cells including total, double-stained, and single-stained cells. *p < 0.05; **p < 0.01. C1–C4, Prolonged training leads to odor discrimination in adrenoceptor-blocked group and restores reliability of pyramidal cell activity. D1–D4, Impaired odor discrimination by adrenoceptor blockade is accompanied by reduced pattern separation between rewarded (S+) and unrewarded (S−) ensembles.