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. 2015 Oct 14;35(41):14070–14075. doi: 10.1523/JNEUROSCI.2690-15.2015

Figure 2.

Figure 2.

APC adrenoceptor blockade prevents similar odor discrimination learning and changes in OB odor representations. A, Schematic of experimental procedures. B1–B6, Impaired odor discrimination by adrenoceptor blockade is accompanied by reduced reliability of mitral and granule cell representations. B1, Correct responses in the drug and saline group with eight training blocks. B2, Example of Arc+ cells in the OB. Blue indicates DAPI staining of nuclei; red indicates Arc signals. White and yellow arrows indicate double- and single-stained Arc+ cells respectively. GC, Granule cell layer; MC, mitral cell layer. Scale bar, 20 μm. B3, OLR of two mitral cell ensembles to the same reward odor (S+) in the drug and saline groups. B4, Distribution of Arc+ mitral cells including total, double-stained, and single-stained cells. B5, OLR of two granule cell ensembles to the same reward odor (S+) in the drug and saline groups. B6, Distribution of Arc+ granule cells including total, double-stained, and single-stained cells. *p < 0.05; **p < 0.01. C1–C4, No difference in pattern separation between rewarded (S+) and unrewarded (S−) mitral cell ensembles in the OBs of the drug and saline groups.