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. 2014 May 21;34(21):7302–7313. doi: 10.1523/JNEUROSCI.5030-13.2014

Figure 7.

Figure 7.

CTA extinction-induced BDNF expression elevation in the IL depends on the BDNF signaling activation in the BLA. A, Schematic representation of the behavior protocol. Rats received bilateral microinfusion of BDNF antibodies or vehicles immediately after CTA extinction test, and the extinction tests were performed for 2 consecutive days. All animals were killed at 0 h or 1.5 h after the second CTA extinction test. The 0 h vehicle group served as a control. B, C, Real-time PCR analysis showing relative BDNF mRNA expression levels after infusion with BDNF antibodies or vehicle into the BLA (B) or IL (C) at 0 h or 1.5 h after the second CTA extinction test normalized to control (n = 8–12 per group). *p < 0.05, compared with the control group (one-way ANOVA). **p < 0.01, compared with the control group (one-way ANOVA). #p < 0.05, compared with the extinction + vehicle group (one-way ANOVA). ##p < 0.01, compared with the extinction + vehicle group (one-way ANOVA). NS, No significance.