Figure 4.

1,25(OH)₂D₃ treatment induces P-gp in 10-week-old Tg2576 mice (a) and reduces soluble hAβ_1–40 and hAβ_1–42 in the brain (b). N/D denotes that levels were below detection limits. For Tg2576 mice, n = 5; for non-Tg mice, n = 6. A one-way ANOVA was used to evaluate differences in Mdr1a/P-gp between groups, with p values determined by Bonferroni's multiple comparisons test. To compare Aβ levels between treated and control Tg2576 mice, p values were determined by Student's two-tailed t test.