Figure 4.

Internal block of the Cav3–Kv4 complex selectively increases firing rate gain in lobule 9 granule cells. A, Representative recordings of current-evoked firing (1 s) in separate granule cells in the absence or presence of a PanKChIP antibody in the electrolyte (1:100 dilution) to block the Cav3–Kv4 interaction. B, C, Average current–frequency plots (B) and mean gain of firing (C) of granule cells in response to stimuli as shown in A in the absence or presence of the internal PanKChIP antibody. Interfering with the Cav3–Kv4 interaction reveals an increase in firing rate gain in lobule 9 but not lobule 2 granule cells. Sample numbers for mean values in bar plots are shown in parentheses. *p < 0.05; **p < 0.01, Student's unpaired t test.