Table 2.
Electrophysiological properties of MePV neuron cell typesa
| Type I (n = 42) | Type II (n = 36) | Type 1 (n = 22) | Type 2 (n = 16) | Type 3 (n = 28) | p | |
|---|---|---|---|---|---|---|
| Vrest (mV) | −72 ± 1 | −64 ± 0.5 | −63 ± 1 | −66 ± 1 | −65 ± 1 | II, 1, 2, 3 ** I |
| Rin (MΩ) | 218 ± 9 | 246 ± 13 | 305 ± 16 | 249 ± 18 | 193 ± 10 | 1 ** I, II, 3; II * 3 |
| τm (ms) | 25 ± 1 | 13 ± 1 | 20 ± 1 | 10 ± 0.5 | 13 ± 1 | I ** 1 *** II, 2, 3 |
| sag ratio | 1 ± 0.004 | 1 ± 0.003 | 0.9 ± 0.01 | 1 ± 0.004 | 0.9 ± 0.01 | I, II, 2 **** 1, 3 |
| Rheobase (pA) | 100 ± 6 | 79 ± 4 | 56 ± 7 | 113 ± 12 | 125 ± 10 | I, 2, 3 *** 1; 3 *** II |
| AP threshold (mV) | −34 ± 1 | −31 ± 1 | −31 ± 1 | −34 ± 1 | −35 ± 1 | II, 1 * 3 |
| AP latency (ms) | 166 ± 23 | 60 ± 16 | 89 ± 9 | 200 ± 45 | 169 ± 35 | I, 2, 3 ** II |
| AP amplitude (mV) | 79 ± 1 | 72 ± 1 | 70 ± 1 | 56 ± 3 | 73 ± 2 | I ** II, 1, 3 **** 2 |
| AP HW (ms) | 0.7 ± 0.02 | 0.6 ± 0.01 | 0.6 ± 0.02 | 0.6 ± 0.03 | 0.7 ± 0.03 | I, 3 * II, 1, 2 |
| fAHP amp (mV) | 19 ± 0.6 | 22 ± 0.4 | 21 ± 0.5 | 25 ± 1 | 17 ± 1 | 2 ** I, II, 1 ** 3 |
| fAHP latency (ms) | 2.5 ± 0.1 | 1.9 ± 0.1 | 1.8 ± 0.1 | 2 ± 0.1 | 2.1 ± 0.1 | I * II, 1, 2, 3 |
| mAHP amp (mV) | 18 ± 1 | 17 ± 1 | 21 ± 1 | 15 ± 1 | 14 ± 1 | 1 * I, II, 2, 3; I ** 3 |
| mAHP latency (ms) | 22 ± 2 | 19 ± 2 | 19 ± 2 | 12 ± 1 | 12 ± 1 | I *** 2, 3; II * 3 |
| AP broadening | 0.2 ± 0.01 | 0.3 ± 0.02 | 0.2 ± 0.02 | 0.3 ± 0.1 | 0.4 ± 0.1 | 3 *** I, 1; II, 2 * I |
| AP amplitude accommodation | 0.1 ± 0.01 | 0.2 ± 0.02 | 0.1 ± 0.02 | 0.2 ± 0.05 | 0.2 ± 0.02 | II, 2, 3 ** I; II, 3 * 1 |
| Firing frequency accommodation | 2 ± 0.3 | 6 ± 1 | 1 ± 0.3 | 1 ± 0.3 | 1 ± 0.2 | II ** I, 1, 2, 3 |
| Maximal firing frequency (Hz) | 42 ± 2 | 60 ± 2 | 57 ± 3 | 110 ± 6 | 53 ± 3 | 2 **** I, II, 1, 3; II, 1 ** I |
aData are mean ± SEM. Definition of electrophysiological properties is explained in Materials and Methods. One-way ANOVA test with a Bonferroni post hoc was used for statistical comparison. Statistical significance was defined as p < 0.05. n, number of cells.
*p < 0.05;
**p < 0.01;
***p < 0.001;
****p < 0.0001.