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. 2014 Jun 18;34(25):8432–8448. doi: 10.1523/JNEUROSCI.1105-14.2014

Figure 6.

Figure 6.

Abnormal lipid composition in raptor mutant spinal cords. A, Quantification of total FAs (TFAs) showed a significant reduction of nonessential FAs (N.Ess.FAs) in raptor mutants, whereas the level of essential FAs (Ess.FAs) did not change. Percentage of saturated, monounsaturated, and polyunsaturated FAs indicated a shift from monounsaturated to polyunsaturated FAs. The ratio of 18:1/18:2, relatively high in normal myelin, was reduced in mutants. B, Phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, and phosphatidyl serine levels showed no change between controls and mutants. C, Cholesterol, ceramides, sphingomyelin, and glycosylceramides were strongly reduced in mutant spinal cords. Lipid species were normalized to the weight of the sample. Error bars indicate SEM. n = 4; *p < 0.05; **p < 0.01; ***p < 0.001.