Skip to main content
. 2014 Jun 11;34(24):8139–8150. doi: 10.1523/JNEUROSCI.5200-13.2014

Figure 10.

Figure 10.

Cx3cr1 deficiency dysregulates microglia activation and increases photoreceptor apoptosis in rd10 retinas. A–D, Cx3cr1 deficiency caused more rod loss in rd10 retinas (C) than in rd10 retinas with Cx3cr1 (A). At P25, cone photoreceptors in rd10/Cx3cr1+/GFP retinas maintain ISs (B), and the ISs of cone photoreceptors in rd10/Cx3cr1GFP/GFP retinas become flattened, and redistribution of red/green opsins (R/G opsin) to cell bodies and cone axonal terminals occurs in cones of rd10/Cx3cr1GFP/GFP retinas (D). E, Quantification of microglial cells that migrated into the ONL in vertical sections of rd10 retinas with or without Cx3cr1 deficiency at P13, P16, and P19. F, The ONL thickness, measured by photoreceptor layers, is significantly different between rd10 retinas with or without Cx3cr1 deficiency at both P19 and P25. Results are presented as means ± SD; n = number of retinas in each group, *p < 0.05 and **p < 0.01. INL, inner nuclear layer; GCL, ganglion cell layer; Scale bar, 20 μm.