Figure 1.

Flowchart of the study. Twenty-three healthy overweight older adults successfully completed 26 weeks of resveratrol intake (200 mg/d) and were pairwise matched to 23 control subjects receiving placebo supplementation. Before and after the intervention/control period, subjects were tested for memory performance and underwent 3T MRI neuroimaging to evaluate resting-state FC, volume, and microstructure of the hippocampus. In addition, fasting blood samples were taken to assess markers of glucose metabolism, lipid profile, inflammatory parameters, and neurotrophic factors.