Figure 1.

Human NR3C1 gene and the CpG region analyzed by bisulfite pyrosequencing. The 5′ region of the NR3C1 gene contains multiple first exons, corresponding to multiple transcriptional start sites and multiple mRNA splice variants. The region analyzed by pyrosequencing is illustrated by enlarged box, below the exon 1F. Numbering is relative to the alternative transcription start site in exon 2. The CpG3 and CpG4 sites are encompassed by the potential NGFI-A binding site. Adapted from Oberlander et al. (2008).