Skip to main content
. 2014 Jul 30;34(31):10274–10284. doi: 10.1523/JNEUROSCI.1526-14.2014

Table 1.

Association of PTSD symptom clusters and DNA methylation of NR3C1 gene promoter in Rwandan mena

PTSD symptom clusters (nmales = 83) NR3C1_CpG1 NR3C1_CpG2 NR3C1_CpG3 NR3C1_CpG4 NR3C1_CpG5 NR3C1_CpG6 NR3C1_CpG7 NR3C1 _CpG8
Intrusionsb
    Spearman's ρ −0.235 −0.039 −0.355 −0.128 −0.203 −0.059 −0.118 −0.18
    p value
        Nominal 0.037* 0.733 0.001*** 0.261 0.073 0.606 0.3 0.112
        Bonferroni correction for 8 CpGs 0.296 1 0.008 1 0.584 1 1 0.896
        Bonferroni correction for 8 CpGs, sex, and 3 PTSD symptom clusters 1 1 0.048 1 1 1 1 1
Avoidanceb
    Spearman's ρ −0.115 −0.033 −0.260 −0.033 −0.101 −0.049 −0.019 −0.074
    p value
        Nominal 0.315 0.772 0.021* 0.77 0.376 0.666 0.87 0.517
        Bonferroni correction for 8 CpGs 1 1 0.168 1 1 1 1 1
        Bonferroni correction for 8 CpGs, sex, and 3 PTSD symptom clusters 1 1 1 1 1 1 1 1
Hyperarousalb
    Spearman's ρ −0.187 −0.097 −0.346 −0.038 −0.165 −0.074 −0.08 −0.053
    p value
        Nominal 0.099 0.396 0.009** 0.74 0.145 0.514 0.483 0.645
        Bonferroni correction for 8 CpGs 0.792 1 0.072 1 1 1 1 1
        Bonferroni correction for 8 CpGs, sex, and 3 PTSD symptom clusters 1 1 0.432 1 1 1 1 1
PDS scoreb,c
    Spearman's ρ −0.207 −0.056 −0.355 −0.081 −0.172 −0.036 −0.078 −0.112
    p value
        Nominal 0.067 0.627 0.001*** 0.476 0.131 0.756 0.496 0.324
        Bonferroni correction for 8 CpGs 0.536 1 0.008 1 1 1 1 1
        Bonferroni correction for 8 CpGs, sex, and 3 PTSD symptom clusters 1 1 0.048 1 1 1 1 1
NR3C1 DNA methylation
    Mean 2.86 1.52 2.84 1.01 1.77 3.52 4.88 1.83
    SD 1.32 1.55 1.56 1.45 1.58 1.81 1.82 1.56

aCorrelation of NR3C1 gene promoter DNA methylation with sum of PTSD-specific symptom subscores according to PDS and DSM-IV. To account for trauma load, PTSD symptom cluster scores were divided by the sum of lifetime traumatic event types. Spearman's correlation ρs coefficients and the corresponding nominal and Bonferroni-corrected p values are shown for each symptom cluster.

bSum of specific symptom clusters corrected for total number of lifetime traumatic events.

cPDS score is not an additional symptom measure, as it represents the sum of the subscores of Intrusions, Avoidance, and Hyperarousal.

***Correlation is nominally significant at the 0.001 level (2-tailed, Spearman's ρ).

**Correlation is nominally significant at the 0.01 level (2-tailed, Spearman's ρ).

*Correlation is nominally significant at the 0.05 level (2-tailed, Spearman's ρ).