Table 1.
The roles of BM and BM-related molecules in presynaptic bouton restrictiona
| Common name | Gene | Method of depletion | Bouton growth defects |
|---|---|---|---|
| Basement membrane components | |||
| Collagen IV α1 | emb-9 | xd51,b189,cg46 | + |
| Collagen IV α2 | let-2 | g30 | + |
| Collagen XVIII | cle-1 | cg120 | + |
| Fibulin-1 | fbl-1 | tk45 | − |
| Hemicentin | him-4 | e1267 | − |
| Laminin αA | lam-3 | RNAi | − |
| Laminin αB | epi-1 | gm57 | − |
| Laminin β | lam-1 | rh219 | −* |
| Laminin γ | lam-2 | RNAi | − |
| Nidogen | nid-1 | cg119 | − |
| Osteonectin | ost-1 | RNAi | − |
| Papilin | mig-6 | ev700 | − |
| Perlecan | unc-52 | e1421,e998 | − |
| Receptors of basement membrane components | |||
| Dystroglycan | dgn-1 | cg121 | − |
| Dystroglycan | dgn-2 | ok209 | − |
| Dystroglycan | dgn-3 | tm1092 | − |
| Glypican | gpn-1 | ok377 | − |
| Glypican | lon-2 | e678 | − |
| Integrin α | ina-1 | gm144 | − |
| Integrin α | pat-2 | RNAi | − |
| Integrin β | pat-3 | pat-3(sp) | −* |
| LAR-RPTP | ptp-3 | ok244 | − |
| Syndecan | sdn-1 | zh20 | − |
| Discoidin domain receptor | ddr-1 | ok874 | − |
| Discoidin domain receptor | ddr-2 | ok574 | − |
| Slit homolog | slt-1 | eh15 | − |
| Related enzymes | |||
| ADAMTS proteinase | gon-1 | e2551/q518 | + |
| ADAMTS proteinase | mig-17 | k113 | − |
| ADAM proteinase | unc-71 | e541 | −* |
| ADAM proteinase | adt-1 | cn30 | − |
| ADAM proteinase | sup-17 | n316 | − |
a+, ectopic boutons; −, no ectopic boutons.
*Axon guidance defect.