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. 2014 Jul 23;34(30):10010–10021. doi: 10.1523/JNEUROSCI.0934-14.2014

Figure 2.

Figure 2.

Retrieval of morphine memory induced dephosphorylation of eIF2α (Ser51) in the BLA but not CeA. A, Timeline of the experiment. B, CPP scores (mean ± SEM) in rats during the baseline preference and CPP test phases. Rats in the morphine groups acquired significant place preference. The data are shown as preference scores (in seconds) during the CPP preference tests (n = 8 per group). *p < 0.05 compared with baseline preference in morphine group. C, D, Phosphorylated eIF2α, ATF4, and total eIF2α protein levels and representative Western blots in the BLA and CeA after exposure to morphine-paired context. The data are expressed as a percentage of phosphorylated eIF2α, ATF4, and total eIF2α in naive control rats (n = 6 per group). In the BLA but not CeA, exposure to the morphine-paired context decreased phosphorylated eIF2α and ATF4 in the morphine group, which time-dependently recovered. *p < 0.05 compared with the no-retrieval (NoR) group.