Figure 3.
Loss of Smarcb1 in hGFAP-positive precursor cells similarly results in hypoplastic cerebella, but not in brain tumor formation. Cerebellar growth in hGFAP-cre::Smarcb1fl/fl was dramatically decreased compared with controls (H&E stains of sagitally cut brains; A, B vs E, F) with lack of foliation and cortical lamination (C, D vs G, H). Moreover, we detected severe lamination disturbances and a thinning of the cerebral cortex (A vs E), indicating that Smarcb1 is similarly important for the development of the forebrain. Scale bars: A, E, 2 mm; B, 500 μm; F, 300 μm; C, D, G, H, 100 μm.