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. 2014 Jul 16;34(29):9574–9589. doi: 10.1523/JNEUROSCI.4302-13.2014

Figure 5.

Figure 5.

CREB SUMOylation enhances spatial learning and memory and increases CREB DNA binding and bdnf mRNA expression. Effects of Lenti-CREBWT and Lenti-CREB sumo-mutant transduction to rat CA1 area on spatial acquisition (A), probe trial performance (B), CREB SUMOylation and CREB DNA binding (C). n = 7 each group. D, ChIP PCR (top) and ChIP qPCR (bottom) showing the effects of Flag-CREBWT and Flag-CREB sumo-mutant transfection on CREB DNA binding to the bdnf promoter. E, Quantitative PCR showing the effects of Flag-CREBWT and Flag-CREB sumo-mutant transfection on bndf mRNA level. F, Effect of Lenti-CREBWT and Lenti-CREB sumo-mutant transduction to rat CA1 area on visible platform learning (n = 4 each group). Data are expressed as mean ± SEM. Biochemical experiments were performed in duplicate. *p < 0.05; **p < 0.01; #p < 0.001.