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PIAS1 siRNA transfection impairs water maze performance and decreases CREB SUMOylation. Effects of PIAS1 siRNA transfection to the rat CA1 area on spatial acquisition (A), probe trial performance (B), endogenous CREB SUMOylation and the expression of different PIAS family proteins (C) are shown. The quantified result of CREB SUMOylation is shown in D. n = 7 each group. Data are expressed as mean ± SEM. *p < 0.05; #p < 0.001.
