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. 2014 Nov 5;34(45):14995–15008. doi: 10.1523/JNEUROSCI.2228-14.2014

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Copyright © 2014 the authors 0270-6474/14/3414995-14$15.00/0

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Figure 6. — Behavioral abnormalities in adult Girdin^SA/SA and Girdin^+/− mice. A, B, Performance in fear-conditioning test in Girdin^SA/SA (A) and Girdin^+/− (B) mice. Context-dependent freezing was measured 1 and 24 h after fear conditioning. Data are expressed as mean ± SEM (n = 8 for 1 h after the conditioning in Girdin^+/+, n = 15 for 24 h after the conditioning in Girdin^+/+, n = 10 for 1 h after the conditioning in Girdin^SA/SA, n = 15 for 24 h after the conditioning in Girdin^SA/SA in A; n = 6 for 1 h after the conditioning in Girdin^+/+, n = 16 for 24 h after the conditioning in Girdin^+/+, n = 6 for 1 h after the conditioning in Girdin^+/−, n = 15 for 24 h after the conditioning in Girdin^+/− in B). **p < 0.01 compared with Girdin^+/+ mice (Student's t test). C, D, Performance in novel object recognition test in Girdin^SA/SA (C) and Girdin^+/− (D) mice. Data are expressed as mean ± SEM (n = 16 for Girdin^+/+, n = 15 for Girdin^SA/SA in C; n = 16 for Girdin^+/+, n = 16 for Girdin^+/− in D). **p < 0.01 compared with Girdin^+/+ mice (Student's t test). E, F, Performance in Morris water maze test in Girdin^SA/SA (E) and Girdin^+/− (F) mice. Path length (swim distance) to find the hidden platform was measured during training trials (days 1–6). Data are expressed as mean ± SEM (n = 14 for Girdin^+/+, n = 14 for Girdin^SA/SA in E; n = 15 for Girdin^+/+, n = 14 for Girdin^+/− in F). Repeated-measures ANOVA for E, genotypes, F_(1,26) = 6.284, p < 0.05; days, F_(5,130) = 47.858, p < 0.01; genotypes × days, F_(5,130) = 1.001, p = 0.4198. Repeated-measures ANOVA for F, genotypes, F_(1,27) = 5.969, p < 0.05; days, F_(5,135) = 51.334, p < 0.01; genotypes × days, F_(5,135) = 1.712, p = 0.1360. *p < 0.05 compared with Girdin^+/+ mice (Tukey–Kramer post hoc test). G, Locomotor activity in a novel environment in Girdin^SA/SA mice. Data are expressed as mean ± SEM (n = 16 for Girdin^+/+; n = 15 for Girdin^SA/SA). Repeated-measures ANOVA, genotypes, F_(1,29) = 6.519, p < 0.05; times, F_(35,1015) = 99.176, p < 0.01; genotypes × times, F_(35,1015) = 2.011, p < 0.01. *p < 0.05 compared with Girdin^+/+ mice (Tukey–Kramer post hoc test). H, Total locomotor activity during 90–120 min in Girdin^SA/SA mice. **p < 0.01 compared with Girdin^+/+ mice (Student's t test). I, Performance in PPI test in Girdin^SA/SA mice. PPI (%) at four different prepulse intensities (69, 73, 77, and 81 dB) in PPI test. Data are expressed as mean ± SEM (n = 15 for Girdin^+/+; n = 14 for Girdin^SA/SA). Repeated-measures ANOVA, genotypes, F_(1,28) = 5.267, p < 0.05; prepulse intensities, F_(3,84) = 46.386, p < 0.01; genotypes × prepulse intensities, F_(3,84) = 0.237, p = 0.8705. *p < 0.05 compared with Girdin^+/+ mice (Tukey–Kramer post hoc test). Behavioral analyses were performed in 7- to 20-week-old mice.