Table 1.

Regions with a significant increase in fMRI signal for increasing prospective gains at the time of incentive presentation (p < 0.001, uncorrected)

Brain region	Laterality	Peak Talairach coordinates (mm)			Peak t value
		x	y	z
Striatum (nucleus accumbens, ventral putamen)*	R	12	14	−11	6.43
Striatum (nucleus accumbens, ventral putamen)*	L	−15	8	−11	5.99
Supplementary motor area*	R	9	2	70	8.04
Thalamus*	L	3	−4	4	7.21
Parietal cortex*	L	−21	−64	58	7.29
Posterior cingulate	R	9	−67	13	5.37
Occipital cortex	L	−12	−70	10	5.93
Dorsolateral prefrontal cortex	R	33	44	31	4.76
Dorsolateral prefrontal cortex	L	−33	38	40	5.11
Insula	R	39	14	−2	4.77
Anterior cingulate	R	9	11	46	5.95

At the time of incentive presentation, no regions showed decreasing activity for increasing prospective gains. Statistically significant activations are those found in a priori regions of interest (familywise error, *p < 0.05) and those regions that survive whole-brain correction for multiple comparisons (at *p < 0.05). Laterality - right (R); left (L); central (C).