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. 2014 Oct 8;34(41):13586–13599. doi: 10.1523/JNEUROSCI.5069-13.2014

Figure 5.

Figure 5.

Increased firing frequencies of DA SN neurons in A53T-SNCA mice are preserved in vitro and occluded by phrixotoxin-2. A, B, Current-clamp traces of whole-cell patch-clamp recordings showing the spontaneous in vitro activity of DA SN neurons in control (A) and A53T-SNCA mice (B). Scale bars, 1 s, 10 mV. C, D, Current-clamp traces of whole-cell patch-clamp recordings showing the spontaneous in vitro activity of DA SN neurons in control (C) and A53T-SNCA mice (D) in the presence of 1 μM phrixotoxin-2. Scale bars, 1 s, 10 mV. E, Mean firing frequencies of DA SN neurons (mean ± SEM) in control and A53T-SNCA mice under control conditions and in the presence of 1 μM phrixotoxin-2. Note the absence of a significant difference between frequencies in controls and A53T-SNCA in 1 μM phrixotoxin-2. One-way ANOVA with Tukey's multiple-comparison test; ***p < 0.0005, **p < 0.005, *p < 0.05.

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