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Gating parameters of Kv4 channels
| Standard whole-cell | WT (n = 9) | A53T (n = 8) | p |
|---|---|---|---|
| Steady-state activation Kv4 (mV) | |||
| V50 | −28.8 ± 0.8 | −30.8 ± 0.5 | ns |
| Slope factor | 5.9 ± 0.7 | 6.0 ± 0.2 | ns |
| Steady-state inactivation Kv4 (mV) | (n = 14) | (n = 11) | ns |
| V50 | −61.4 ± 0.6 | −60.0 ± 0.8 | ns |
| Slope factor | 5.3 ± 0.3 | 5.0 ± 0.3 | ns |
| Nucleated outside-out | (n = 6) | (n = 4) | ns |
| Tau-inactivation@ −30 mV (ms) | 13.8 ± 1.3 | 13.1 ± 0.9 | ns |
| Tau-recovery@ −80 ms (ms) | 9.8 ± 0.2 | 10.9 ± 0.9 | ns |
