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. 2019 Jun 26;13:636. doi: 10.3389/fnins.2019.00636

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Copyright © 2019 Peng, Yang, Yin, Ge, Wang, Zhang, Zhang, Xu, Dai, Xie, Li, Si and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of the TGF-β2/Smad3 and Shh/Gli signaling pathway in the hippocampus of rats with ISO post-conditioning after cerebral I/R injury. (A) showed CA1 region IF of TGF-β2. → indicates the position of TGF-β2. (B) showed CA1 region IF of Shh. → indicates the position of Shh. (C) showed CA1 region IF of Gli1. → indicates the position of Gli1. (D) showed the mean fluorescence density of TGF-β2. (E) showed the mean fluorescence density analysis of Shh. (F) showed the mean fluorescence density analysis of Gli1. (G) Proteins expression levels of the TGF-β2/Smad3 and Shh/Gli signaling pathways. (H) Western blot analysis of the TGF-β2/Smad3 signaling pathway. (I) Western blot analysis of the Shh/Gli signaling pathway. Scale bars = 100 μm. Data are shown as the mean ± SD (n = 3). ^∗ P < 0.05 vs. ISO; # P < 0.05 vs. ISO + Pir; P < 0.05 vs. ISO + SIS3; & P < 0.05 vs. ISO + CYC.

Inline graphic — Expression of the TGF-β2/Smad3 and Shh/Gli signaling pathway in the hippocampus of rats with ISO post-conditioning after cerebral I/R injury. (A) showed CA1 region IF of TGF-β2. → indicates the position of TGF-β2. (B) showed CA1 region IF of Shh. → indicates the position of Shh. (C) showed CA1 region IF of Gli1. → indicates the position of Gli1. (D) showed the mean fluorescence density of TGF-β2. (E) showed the mean fluorescence density analysis of Shh. (F) showed the mean fluorescence density analysis of Gli1. (G) Proteins expression levels of the TGF-β2/Smad3 and Shh/Gli signaling pathways. (H) Western blot analysis of the TGF-β2/Smad3 signaling pathway. (I) Western blot analysis of the Shh/Gli signaling pathway. Scale bars = 100 μm. Data are shown as the mean ± SD (n = 3). ^∗ P < 0.05 vs. ISO; # P < 0.05 vs. ISO + Pir; P < 0.05 vs. ISO + SIS3; & P < 0.05 vs. ISO + CYC.